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clobetasol propionate

clobetasol propionate

CAS: 25122-46-7

Molecular Formula: C25H32ClFO5

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clobetasol propionate - Names and Identifiers

Name clobetasol propionate
Synonyms cgp9555
Dermovate
17-propionate
Cloβsol propionate
clobetasol propionate
CLOBETASOLE PROPIONATE
CLOBETASOL 17-PROPIONATE USP
Clobetasol 17- propionate solution,100ppm
21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
(11beta,16beta)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
(8xi,11beta,14xi,16beta)-21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS 25122-46-7
EINECS 246-634-3
InChI InChI=1/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17?,18?,19-,22-,23-,24-,25-/m0/s1
InChIKey CBGUOGMQLZIXBE-XGQKBEPLSA-N

clobetasol propionate - Physico-chemical Properties

Molecular FormulaC25H32ClFO5
Molar Mass466.97
Density1.1653 (estimate)
Melting Point195.5-1970C
Boling Point569.0±50.0 °C(Predicted)
Specific Rotation(α)D +103.8° (c = 1.04 in dioxane)
Flash Point297.9°C
Solubility Soluble in chloroform, dissolved in ethyl acetate, slightly soluble in methanol and ethanol, insoluble in water
Vapor Presure2.58E-15mmHg at 25°C
AppearanceWhite-like or yellowish crystalline powder
pKa12.88±0.70(Predicted)
Storage ConditionKeep in dark place,Sealed in dry,2-8°C
Refractive Index1.56
MDLMFCD00058499
UseFor adrenocorticotropic hormone and adrenocorticotropic hormone drugs

clobetasol propionate - Risk and Safety

Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
R62 - Possible risk of impaired fertility
R53 - May cause long-term adverse effects in the aquatic environment
R48/20/21 -
R61 - May cause harm to the unborn child
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37 - Wear suitable protective clothing and gloves.
S53 - Avoid exposure - obtain special instructions before use.
WGK Germany2
RTECSTU3725000
HS Code29372290

clobetasol propionate - Standard

Authoritative Data Verified Data

This product is 16B-methyl-llB-hydroxy -17-(1-oxopropyl) -9-fluoro-21-chloro-pregnan-1, 4-dien-3, 20-dione. Based on the dry product, the content of C25H32CIFO5 should be 97.0% ~ 103.0%.

Last Update：2024-01-02 23:10:35

clobetasol propionate - Trait

Authoritative Data Verified Data
  • This product is white to yellowish crystalline powder.
  • This product is soluble in three gas methane, dissolved in ethyl acetate, slightly soluble in methanol or ethanol, insoluble in water.

melting point

The melting point of this product (General rule 0612) is 194~198°C, and it is decomposed at the same time during melting.

specific rotation

take this product, precision weighing, plus dioxane dissolution and quantitative dilution of about 10mg per lml solution, according to the law (General 0621), the specific rotation should be 99 ° to ten 105 °.

Last Update：2022-01-01 11:35:26

clobetasol propionate - Differential diagnosis

Authoritative Data Verified Data
  1. take a small amount of this product, add 1 ml of ethanol, mix, heat for 2 minutes on a water bath, add nitric acid (1-2 )2ml, shake well, add several drops of silver nitrate test solution, and generate white precipitate.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 592).
  3. This product shows the identification reaction of organic fluorine compounds (General rule 0301).
Last Update：2022-01-01 11:35:26

clobetasol propionate - Exam

Authoritative Data Verified Data

Related substances

take this product, dissolve and dilute with mobile phase to make a solution containing about 0.5mg per 1 ml as a test solution; Take 2ml for precision measurement and put it in a 100ml measuring flask, dilute to the scale with the mobile phase, shake, and serve as a control solution. According to the chromatographic conditions under the item of content determination, 20ul of each of the test solution and the control solution are accurately measured. Human liquid chromatograph is injected into the mountain respectively, and the chromatogram is recorded to 2.5 times of the retention time of the main component chromatographic peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (1.0%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 1.25 times (2.5%) of the main peak area of the control solution.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

Heavy metals

take this product 1.Og, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.

Last Update：2022-01-01 11:35:27

clobetasol propionate - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with octylsilane as filler; 0.05mol/L sodium dihydrogen phosphate solution (adjusted to pH 85% with 2.5 phosphoric acid solution)-acetonitrile-methanol (425:475:100) mobile phase; The detection wavelength was 240mn. The number of theoretical plates is not less than 5000 calculated as clobetasol propionate peak.

assay

take this product, precise weighing, dissolving with methanol and quantitatively diluting it to make a solution containing about 40ug per lml, inject L01 into liquid chromatography with precise volume, record chromatogram; Take clobetasol propionate control, same method determination. According to the external standard method to calculate the peak area, that is.

Last Update：2022-01-01 11:35:28

clobetasol propionate - Category

Authoritative Data Verified Data

adrenocortical hormone drugs.

Last Update：2022-01-01 11:35:28

clobetasol propionate - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 11:35:28

clobetasol propionate - Clobetasol Propionate Cream

Authoritative Data Verified Data

This product contains clobetasol propionate (C25H32CIFO5) should be 90.0% ~ 110.0% of the label amount.

trait

This product is white cream.

identification

In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.

examination

should comply with the relevant provisions under Cream (General rule 0109).

Content determination

  • measured by high performance liquid chromatography (General 0512).
  • chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (65:35) as mobile phase; The detection wavelength was 240nm. The number of theoretical plates shall not be less than 2000 based on clobetasol propionate peak. The separation degree between the peak of Clobetasol propionate and the peak of internal standard substance shall meet the requirements. Preparation of internal standard solution fluorine acetate was easily taken, dissolved in methanol and diluted to prepare a solution containing about 0.15mg per 1ml.
  • determination: take an appropriate amount of this product (about 1 mg equivalent to clobetasol propionate), weigh it accurately, put it in a 50ml measuring flask, add 5ml of internal standard solution accurately, and add about 30ml of methanol, heat in a 60°C water bath for 5 minutes, carefully shake to dissolve clobetasol propionate, let it cool, dilute with methanol to the scale, shake well, cool in an ice bath for more than 2 hours, take it out and quickly filter, the filtrate was taken to room temperature as a test solution, and 20u1 was injected into the liquid chromatograph to record the chromatogram, add methanol to dissolve and dilute quantitatively to make a solution containing about 0.2mg per 1ml. Take 5ml of the solution and 5ml of the internal standard solution precisely, put them in a 50ml measuring flask, and dilute to the mark with methanol, shake well, take a liquid chromatograph and record the chromatogram. According to the internal standard method to calculate the peak area, that is.

category

Same as clobetasol propionate.

specification

(l)10g:2mg (2 ) l0g:5mg

storage

sealed and stored in a cool place.

Last Update：2022-01-01 11:35:29
clobetasol propionate
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Clobetasol Propionate Visit Supplier Webpage Request for quotation
CAS: 25122-46-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: clobetasol propionate Request for quotation
CAS: 25122-46-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Clobetasol propionate Visit Supplier Webpage Request for quotation
CAS: 25122-46-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
SHANDONG OCTAGON CHEMICALS LIMITED
Product Name: clobetasol propionate Request for quotation
CAS: 25122-46-7
Tel: 15589503653
Email: sales@octagonchem.com
Mobile: 15589503653
QQ: 2283421579 Click to send a QQ messageSend QQ message
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clobetasol propionate
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